柳欣
博士 药学院助理教授 Xin.Liu@xjtlu.edu.cn
西浦慧湖药学院助理教授
发表文献
    Y. Wang, J. Li, D. Huang, Y. Hao, B. Li, K. Wang, B. Chen, T. Li and X, Liu. Comparing Bayesian-Based Reconstruction Strategies in Topology-Based Pathway Enrichment Analysis. Biomolecules. 12(7):906 (2022).
    H. Zha, Y. Hao and X. Liu. Developing a multi-task edge-attention based graph deep learning algorithm for kinase polypharmacology profiling. 2022 14th International Conference on Bioinformatics and Biomedical Technology (ICBBT), 2022.
    T. Wang and X. Liu. A Graph Convolution-Transformer Neural Network for Drug-Target Interaction Prediction. 2022 14th International Conference on Bioinformatics and Biomedical Technology (ICBBT), 2022.
    J. Chen, Y. Hao, T. Wang, D. Huang and X. Liu. Discovery of Stomach Adenocarcinoma Biomarkers by Consensus Scoring of Random Sampling and Machine Learning Modeling. 2022 10th International Conference on Bioinformatics and Computational Biology (ICBCB), 2022, pp. 112-115X.
    Liu, F. Zhu, X.H. Ma, Z. Shi, S.Y. Yang, Y.Q. Wei and Y.Z. Chen. Predicting Targeted Polypharmacology for Drug Repositioning and Multi-Target Drug Discovery. Curr Med Chem. 20(13):1646-1661 (2013).
    X. Liu, Z. She, Y. Xue, Z.R. Li, S.Y. Yang and Y.Z. Chen. In silico prediction of adverse drug reactions and toxicities based on structural, biological and clinical data. Curr Drug Saf. Jul 1;7(3):225-37 (2012).
    X. Liu, F. Zhu, X.H. Ma, L, Tao, J.X. Zhang, S.Y. Yang, Y.C. Wei and Y.Z. Chen. The Therapeutic Target Database: an internet resource for the primary targets of approved, clinical trial and experimental drugs. Expert Opin Ther Targets. 15(8):903-12 (2011).
    S.Y. Chen, P. Zhang, X. Liu, C. Qin, L. Tao, C. Zhang, S.Y. Yang, Y.Z. Chen, W.K. Chui. Towards cheminformatics-based estimation of drug therapeutic index: Predicting the protective index of anticonvulsants using a new quantitative structure-index relationship approach. J. Mol. Graph. Model. 67:102-110 (2016).
    X.H. Ma, F. Zhu, X. Liu, Z. Shi, J.X. Zhang, S.Y. Yang, Y.Q. Wei and Y.Z. Chen. Virtual screening methods as tools for drug lead discovery from large chemical libraries. Curr Med Chem. 19(32):5562-71 (2012).
    B.C. Han, X.H. Ma, R.Y. Zhao, J.X. Zhang, X.N. Wei, X.H. Liu, X. Liu, C.L. Zhang, C.Y. Tan, Y.Y. Jiang and Y.Z. Chen. Development and experimental test of support vector machines virtual screening method for searching Src inhibitors from large compound libraries. Chem Cent J. 6:139 (2012).
    F. Zhu, X.H. Ma, C. Qin, L. Tao, X. Liu, Z. Shi, C.L. Zhang, C.Y. Tan, Y.Y. Jiang and Y.Z. Chen. Drug Discovery Prospect from Untapped Species: Indications from Approved Natural Product Drugs. PLoS ONE. 7(7):e39782 (2012).
    F. Zhu, Z. Shi, C. Qin, L. Tao, X. Liu, F. Xu, L. Zhang, Y. Song, X.H. Liu, J.X. Zhang, B.C. Han, P. Zhang and Y.Z. Chen. Therapeutic Target Database Update 2012: A Resource for Facilitating Target-Oriented Drug Discovery. Nucleic Acids Res. 40(D1):D1128-D1136 (2012).
    F. Zhu, C. Qin, L. Tao, X. Liu, Z. Shi, X.H. Ma, J. Jia, Y. Tan, C. Cui, J.S. Lin, C.Y. Tan, Y.Y. Jiang, and Y.Z. Chen. Clustered patterns of species origins of nature-derived drugs and clues for future bioprospecting. Proc. Natl. Acad. Sci. U. S. A. 108(31):12943-8 (2011).
    F. Zhu, C.J. Zheng, L.Y. Han, B. Xie, J. Jia, X. Liu, M.T. Tammi, S.Y. Yang, Y.Q. Wei and Y.Z. Chen. Trends in the Exploration of Anticancer Targets and Strategies in Enhancing the Efficacy of Drug Targeting. Curr Mol Pharmacol. 1(3):213-232 (2008).
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研究领域
①肿瘤系统生物学：通过对疾病相关的信号/代谢通路及通路之间的关联进行定性分析和定量模拟，在系统层面辅助揭示人类疾病发生及发展的分子机制，指导药物靶点的筛选。
②AI辅助药物设计：基于深度学习算法，建立小分子及靶点之间的结合活性预测模型；对超大规模化合物数据库的检索和活性预测，筛选潜在的先导化合物。
应用场景
生物信息、计算机辅助药物设计、人工智能药物设计
工作经历
2019 年 2 月起至今，西交利物浦大学助理教授
2016 - 2019，生物信息部经理，上海吉凯基因化学技术有限公司。
2013 - 2016 年，生物信息主管，上海中科新生命生物科技有限公司。
教育背景
2013年 - 新加坡国立大学，博士
2007年 - 同济大学，工学学士
科研项目
产学研合作
专利项目

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