张杰
副教授 西浦慧湖药学院 Jie.Zhang03@xjtlu.edu.cn
张杰博士是西交利物浦大学慧湖药学院博士生导师、江苏省标准化专家、江苏省“揭榜挂帅”技术转移审评专家、苏州市领军人才联合会理事、苏州工业园区女科学家联合会副会长、苏州工业园区医疗器械妇联副主席。先后获得金鸡湖领军人才、姑苏领军人才、江苏省三八红旗手等称号。2009年开始，张杰博士将植物干细胞技术与生物制药技术用于名贵中草药培育，建立了干细胞化中草药培育平台，填补了国内空白。干细胞化后的铁皮石斛具备多领域的功能，极大减少了用量，数百倍提高了生产率。
发表文献
    1. Zhang Jie, Xu Fengguo. Study on liquid culture system of dendrobium candidum with high yield and high biological activity. Jiangsu Agricultural Science, 2019, 47(6): 43-47
    2. Zhao Lianxu, Zhang Jie, Meng Ling, et al. Modification of the brain-derived neurotrophic factor gene: a portal to transform mesenchymal stem cells into advantageous engineering cells for neuroregeneration and neuroprotection. Exp Neurol. 2004; 190(2):396-406
    3. Zhao LX, Zhang J, Xu XH, Pei XT. Stem cell and gene therapy: theory, technology and the prospectof application. StemCell& Cellular Therapy 2003; 1(2):10-17
    4. ZHANG Jie, SHAN Qing, MA Ping, JIANG Yanming, CHEN Peng, WEN Jingxia, ZHOU You, QIAN Huanwen & PEI Xuetao，Differentiation potential of bone marrow mesenchymal stem cells into retina in normal and laser-injured rat eye，SciChinaC Life Sci. 2004 Jun; 47(3):241-250.
    5. Zhang Jie, Shan Qing, Ma Ping et al. Bone marrow mesenchymalstem cells can differentiate into retina in normal and laser-injured rat eye. Sci China C Life Sci (Chinese). 2004; 34(1): 41~48
    6. Zhang Jie, Shan Qing, Ma Ping et al. Observation of bone marrow mesenchymal stem cells aftersubretinally transplanted into laser-injured rat retina. Zhonghua Yi Xue Za Zhi. 2003 Nov; 83(22):1993-8.
    7. Zhang Jie, Shan Qing, Ma Ping et al. Bone Marrow Mesenchymal Stem Cells Can Differentiate Into Retina-like Structure in situ. Clin J.Ophthalmol. 23（2）：82-85
    8. Zhang Jie, Shan Qing, Ren Hua et al. The image analysis of laser-burn corneal lesions after interleukin-1receptorantagonisttreatment. Clin.J. Laser Med. Surg. 10(4): 230-233, 2001
    9. Zhang Jie, Shan Qing, Wu Xiaobing et al. Evaluation of Adeno-Associated Virus-Mediated Gene TransferInto The Rabbit Retina.Journalof Tumor markerOncology 16(4): 287, 2001
    10. Jie Zhang Qing Shan Huanwen Qian et al. Stable Expression of Human bcl-2 Antisense RNA Promotes Apoptosis of Human Gastric Cancer Cell Line SGC7901. Journal of Tumor marker Oncology 16(4): 365, 2001
    11. Zhang Jie, Qian Huanwen, Shan Qing et al. Therapeutic effect of recombinant human basic fibroblast growth factor on laser induced retina injuries in rhesus monkeys. Clin. J. Laser Med. Surg. 8(2): 92-95, 1999
    12. Zhang Jie, Peng Weidan, Wang Duoning et al. The construction and evaluation of expression efficiency of an inducible mammalian _expression vector. J. Fourth Mil. Med. Univ. 20(4): 280-283, 1999
    13. Zhang Jie, Peng Weidan, Hui Hongxiang et al. Inducible _expression of bcl-2 antisense RNA promtes apoptosis of human gastric cancer cell line. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (ACTA Biochimica et Bipphysica Scinica), 31 (3): 279-283, 1999 Pubmed ID:12136178 (In Chinese)
    14. Zhang Jie, Peng weidan, Hui Hongxiang et al. the construction of a inducible mammalian _expression vectorwithmultyclone sites.J. FourthMil. Med.Univ. 19(2): 229-230, 1998
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研究领域
① 干细胞来源的白石斛芽（SCDCS）对糖尿病相关炎症的分子机制
② SCDCS对消化系统炎症的分子机制
③ SCDCS 对过敏性疾病如过敏性鼻炎和系统性红斑狼疮的分子机制
④ 干细胞化植物新品系的规模化生产研发
应用场景
新植物原料开发
工作经历
2016年至今 苏州普兰特干细胞生物科技有限公司 企业家、董事长
2009 - 2013 联合动力医药科技有限公司（UP-Pharma），企业家，副总裁，QUA总监
2007 - 2009 无锡雀巢生物科技有限公司 企业家、CEO
2003 - 2006 三生制药（纳斯达克三生制药，01530.HK），中国沉阳研究院副院长
1998 - 2000 北京军事医学科学院放射医学研究所激光医学部助理研究员
教育背景
2003 博士，干细胞分化，军事医学科学院
1998 硕士，分子生物学，第四军医大学
科研项目
基于生物制药技术的中草药培育及产业化
产学研合作
to be updated
专利项目
1: ZHANG JIE. A large-scale cell culture process for dendrobium officinale Kimura et Migo. Publication No. : CN201610305801A.
2: ZHANG JIE. A dendrobium embryoid large-scale culture process. Publication No. : CN107347635A.
3: ZHANG JIE; WANG XINYI; WU HONGSHENG. Culture medium for increasing content of dendrobium officinale immature-stem extract and preparation method thereof. Publication No. : CN109548641A.
4: ZHANG JIE; WANG XINYI; WU HONGSHENG. Humic acid culture medium for improving growth speed of dendrobium candidum young stems and preparation method thereof. Publication No. : CN109548626A.
5: ZHANG JIE; WANG XINYI; WU HONGSHENG. Polysaccharide liquid culture medium and preparation method thereof. Publication No. : CN109548624A.
6: ZHANG JIE; WANG XINYI; WU HONGSHENG. Method for detecting polysaccharides in dendrobium officinale shoots. Publication No. : CN109738427A.
7: ZHANG JIE; WANG XINYI; WU HONGSHENG. Filtering method suitable for dendrobium officinale tender shoot stock solution. Publication No. : CN109793691A.
8: ZHANG JIE; WANG XINYI; WU HONGSHENG. Filtering method suitable for dendrobium officinale dry bud stock solution. Publication No. : CN109793692A.
9: ZHANG JIE; WANG XINYI; WU HONGSHENG. Liquid culture medium suitable for tender stems of dendrobium officinale and preparation method of liquid culture medium. Publication No. : CN109662030A.
10: ZHANG JIE; WANG XINYI; WU HONGSHENG. Liquid culture medium suitable for tender stems of Dendrobium officinale and preparation method thereof. Publication No. : CN109548625A.
11: ZHANG JIE; WANG XINYI; WU HONGSHENG. Liquid culture medium suitable for immature stems of dendrobium officinale and preparation method thereof. Publication No. : CN109601382A.
12: LOU JING;GENG JIANLING;ZHANG JIE. Hemopoietin analogue. Publication No. : CN103073631A.
13: LOU JING;GENG JIANLING;ZHANG JIE. New erythrocyte-stimulating factor analogues. Publication No. : CN101337988B.
14: JIE ZHANG;LU JUN;SHIYANG SHEN. 96-hole cell culture plate without edge effect. Publication No. : CN101348767B.

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